
Annihilation(2018)
A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.


“She's not human...not entirely.”
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.

Adrien Brody
Clive

Sarah Polley
Elsa

Delphine Chanéac
Dren

David Hewlett
Barlow

Abigail Chu
Young Dren

Stephanie Baird
Elsa / PD

Brandon McGibbon
Gavin

Amanda Brugel
Melinda Finch

Simona Măicănescu
Joan Chorot
Splice is a horror, science fiction film released in 2010 exploring themes of experiment, genetics, dna, gene manipulation, genetic engineering, disturbed. Directed by Vincenzo Natali, it stars Adrien Brody, Sarah Polley, Delphine Chanéac. Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
Discover titles like Splice — ranked by similarity and community votes
We found 15 movies similar to Splice
If you enjoyed Splice, you'll love these handpicked recommendations. Each title below shares similar themes, tone, and storytelling style. Our algorithm analyzes genres, keywords, director filmography, and cast connections to find the closest matches. Whether you're looking for the same emotional depth, narrative structure, or visual style, these picks are curated to deliver the best viewing experience for fans of Splice.

A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.

A plane crash surviving attorney stumbles upon a mysterious island and is shocked to discover that a brilliant scientist and his lab assistant have found a way to combine human and animal DNA—with horrific results.

The crew of the colony ship Covenant, bound for a remote planet on the far side of the galaxy, discovers what they think is an uncharted paradise but is actually a dark, dangerous world.

In 1993, the Search for Extra Terrestrial Intelligence Project receives a transmission detailing an alien DNA structure, along with instructions on how to splice it with human DNA. The result is Sil, a sensual but deadly creature who can change from a beautiful woman to an armour-plated killing machine in the blink of an eye.

Amanda's deathbed request to her son, John, was for him to destroy all the lab notes etc. from her last experiment. She also blurts out he had a brother. At the funeral John meets Melissa, who claims to be his mother's biggest fan. Together with some of John's friends they go to Amanda's house, but none are prepared for what they find there.

Several teenagers in a small-town in Colorado concoct a July 4th prank based on a frightening legend that goes awry when their friend ends up accidentally killed; however, the teens agree to keep their involvement a secret from the authorities, who continue to search for the man who apparently killed their friend. A year later, with the July 4th celebration coming up again, the teenagers realize that they're being stalked by someone who clearly intends on keeping the horrible legend alive by killing them off.

When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.

In the distant future, a federation marshal arrives at a research lab on a remote planet where a genetic experiment has gotten loose and begins feeding on the dwindling scientific group.

In Arborville, California, three high school students try to protect their hometown from a gelatinous alien life form that engulfs everything it touches.

A boy takes in a stray dog, later finding out that it's an ultra-intelligent runaway from a genetic research lab. Unbeknownst to him, the dog is being stalked by another escaped creature that's not quite so friendly.

An obsessed scientist conducts profane experiments in evolution, eventually establishing himself as the self-styled demigod to a race of mutated, half-human abominations.

After an African dinosaur ancestor of the crocodile is found, Dr. Campbell uses its DNA to create prototypes at Paula Kennedy's Gereco lab.

The Resonator, a powerful machine that can control the sixth sense, has killed its creator and sent his associate into an insane asylum. When a psychiatrist becomes determined to continue the experiment, she unwittingly opens the door to a hostile parallel universe.

A group of strangers find themselves trapped in a maze-like prison. It soon becomes clear that each of them possesses the peculiar skills necessary to escape, if they don't wind up dead first.